SharePoint (SP) Office 365 (O365)
Installation

Standalone installation

Yes (SP) NA (O365)

Web farm installation

Yes (SP) NA (O365)

Licensed team sites

Yes (SP) NA (O365)

Cloud/Multi-tenant

NA (SP) Yes (O365)
Workflow Designer

Drag and drop designer

Yes (SP) Yes (O365)

Print

Yes (SP) Coming Soon (O365)

Zoom to view

Yes (SP) Coming Soon (O365)

Label workflows

Yes (SP) Yes (O365)

Cross Broswer Support

No (SP) Yes (O365)
Reporting and Management

User-based workflow tracking

Yes (SP) Coming Soon (O365)

Summary statistics, reports, and charts

Yes (SP) Coming Soon (O365)

Individual workflow history & verbose logging

Yes (SP) Coming Soon (O365)

Log in the history list

Yes (SP) Coming Soon (O365)

User access control

Yes (SP) Coming Soon (O365)

Workflow change approval

Yes (SP) Coming Soon (O365)
Logic and Flow

Action set

Yes (SP) Coming Soon (O365)

Loop and parallel actions, Run-if condition

Yes (SP) Yes (O365)

Filter, switch action

Yes (SP) Coming Soon (O365)

State machine

Yes (SP) Yes (O365)
User interaction

InfoPath form generation/support

Yes (SP) No (O365)

Delegate workflow task

Yes (SP) Coming Soon (O365)

Create task

Yes (SP) Yes (O365)

Approval, review, and multi-outcome tasks

Yes (SP) Coming Soon (O365)

Email based natural language approval

Yes (SP) Coming Soon (O365)

Notifications and reminders

Yes (SP) Yes (O365)
Operations

Date, and math operations

Yes (SP) Yes (O365)

Pause, stop, and wait for update

Yes (SP) Yes (O365)

String operations

Yes (SP) Coming Soon (O365)
Publishing

Copy to FileShare, Copy to SharePoint

Yes (SP) NA (O365)

Submit to record center

Yes (SP) NA (O365)
Site, Libraries and Lists

Create/delete sites and site collections

Yes (SP) Coming Soon (O365)

Check In/Check Out/Cancel Check Out on items

Yes (SP) Coming Soon (O365)

Create/Copy/Update/Delete an Item

Yes (SP) Yes (O365)

Create list

Yes (SP) Coming Soon (O365)

Set approval status

Yes (SP) Coming Soon (O365)

Set field value

Yes (SP) Yes (O365)

Set item provisions

Yes (SP) Yes (O365)
Account Provisioning

Add/remove user 

Yes (SP) Yes (O365)

Create/Update/Decommission user account

Yes (SP) Yes (O365)

Create/remove  security group

Yes (SP) Yes (O365)

Enable Lync/OCS

Yes (SP) Yes (O365)

Reset passwords

Yes (SP) Yes (O365)
User Profile Management

Query user profiles

Yes (SP) Yes (O365)

Create/Update/Delete user profiles

Yes (SP) Yes (O365)
Customization & Re-Use

Reusable and site workflows

Yes (SP) Yes (O365)

Content Types, User defined actions

Yes (SP) Coming Soon (O365)

Custom context data

Yes (SP) Coming Soon (O365)

Export to Visual Studio

Yes (SP) Coming Soon (O365)

Import/Export workflow between sites

Yes (SP) Yes (O365)
Connectors

Nintex Connectors (i)

Yes (SP) Yes (O365)

3rd Party Connectors (ii)

Yes (SP) Yes (O365)
System Requirements

Browsers

IE 8 or higher (SP) IE 9, IE 10, Chrome, Firefox (O365)

SharePoint

Server 2010/2013 or Foundation 2010/2013 (SP) NA (O365)

Office 365

NA (SP) Enterprise Edition (E1/E3/E4)^(iii) (O365)

SQL Server

2008 R2 SP1 or 2012 (SP) NA (O365)

Windows Server

2008 R2 or 2012 (SP) NA (O365)
(i) Visit nintex.com/connectors for details
(ii) Visit nintex.com/3rdpartyconnectors for details
(iii) Needs Workflow 2013 Engine and App features